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Official websites use. Share sensitive information only on official, secure websites. Grassi, 74, Milano, Italy; samari1 tin. There are limited evidence based data concerning the use of azathioprine in ulcerative colitis.
The outcome of the treatment was defined as 1 success, indicating induction of clinical and endoscopic remission and steroid discontinuation, or 2 failure, indicating the absence of clinical and endoscopic remission and therefore the need for at least one further cycle of systemic steroids to control symptoms, apart from the initial one, or colectomy. Ulcerative colitis UC is a chronic disease characterised by diffuse inflammation of the colonic mucosa associated with a dysregulation of the mucosal immune system.
In this context, therapeutic options include either prolonged systemic corticosteroid therapy or surgical treatment. To reduce the need for steroids and consequent side effects, and more importantly, to avoid colectomy, various alternative pharmacological approaches have been attempted.
However, while ciclosporin has been shown to be effective in the treatment of severe refractory UC, 8 , 9 , 10 the therapeutic role of the remaining immunosuppressive agents is not yet conclusively established. As far as infliximab is concerned, the available data are conflicting, 11 , 12 , 13 , 14 , 15 , 16 and the results of large, randomised, controlled trials are soon expected.
The study protocol was defined in accordance with the declaration of Helsinki and was approved by the ethics committee of the hospital. Patients gave written informed consent before entering the study.