Official websites use. Share sensitive information only on official, secure websites. Correspondence: A. Of patients enrolled, Most related TEAEs were cutaneous and occurred during the first 3 months.
Signs and symptoms of local tolerability were mostly mild or moderate and severe signs, and symptoms were reported for 2. Local irritation increased during the first week of treatment on the face and up to Weeks 2 to 4 on the trunk with both decreasing thereafter. Success rates increased to Acne is estimated to affect 9. Facial and truncal acne are considered pathophysiologically and clinically similar, with both locations presenting comparable types of lesions, although it may be possible to treat acne in both locations with similar therapeutic approaches.
Currently, topical retinoids are the mainstay of acne treatment, with adapalene, tretinoin and tazarotene available in various concentrations, formulations and combinations as well as orally administered isotretinoin.
Retinoids can be combined with other topical therapies such as benzoyl peroxide or topical antibiotics, as well as systemic treatments including antibiotics and or oral contraceptives in more severe cases. It has a good in vivo metabolic stability in cultured keratinocytes and is rapidly metabolized in human liver microsomes, predicting an improved safety profile due to low systemic levels. The study was conducted between February and February The study complied with all local legal requirements for the conduct of a clinical study and was conducted in accordance with good clinical practices and the Principles of the Declaration of Helsinki.
Prior to the inclusion of any patient, the study received local ethics committee or local independent review board approval. Patients provided written informed consent before participation. The study was registered in the US ClinicalTrials. In total, patients were to be enrolled at 32 sites in Europe 18 sites and the USA 14 sites. After the first application of trifarotene at study site, patients were instructed to apply for the first 12 weeks trifarotene at home once daily in the evening after washing and drying the skin.
