Official websites use. Share sensitive information only on official, secure websites. Corresponding author information: Shilpa D. In vivo electrophysiological recordings are widely used in neuroscience research and video-electroencephalography vEEG has become a mainstay of preclinical neuroscience research, including studies of epilepsy and cognition. Thus, controls provide mainly a reference measurement for the experimental test.
However, interpretation of rodent vEEG studies relies on documented differences in frequency, morphology, type, location, behavioral state dependence, reactivity and functional or structural correlates of specific EEG patterns and features between control and test groups. This paper will focus on the vEEG of standard laboratory rodent strains with the aim of developing a small set of practical guidelines that can assist researchers in the design, reporting, and interpretation of future vEEG studies.
To this end, we will: 1 discuss advantages and pitfalls of common vEEG techniques in rodents and propose a set of recommended practices and 2 present EEG patterns and associated behaviors recorded from adult rats of a variety of strains. We will describe the defining features of selected vEEG patterns brain-generated or artifactual and note similarities to vEEG patterns seen in adult humans.
We will note similarities to normal variants or pathological human EEG patterns and defer their interpretation to a future report focusing on rodent seizure patterns. In vivo electrophysiological observations and recordings are widely used for many types of neurobiological investigation. This is especially true for investigations into the underlying causes, potential treatments, and strategies for prevention of epilepsy.
This paper proposes recommendations for the electrophysiological investigation and monitoring studies [mainly video-EEG vEEG ] of rodents used in epilepsy and epileptogenesis preclinical research.
