Official websites use. Share sensitive information only on official, secure websites. Correspondence: Eduardo L. We assessed efficacy of a carrageenan-based gel compared to a placebo gel in increasing the clearance of anal HPV infections among gay, bisexual, and other men who have sex with men gbMSM. There were no remarkable differences for analyses at the HPV type level or by human immunodeficiency virus status.
Keywords: carrageenan, gel, HIV, HPV, human papillomavirus, gay, bisexual, and other men who have sex with men, men who have sex with men, microbicide, randomized controlled trial. Use of a carrageenan-based gel prior to and during receptive anal intercourse compared to use of a placebo gel was not associated with anal human papillomavirus clearance among gay, bisexual, and other men who have sex with men in an interim analysis of a phase 2b, double-blind, randomized controlled trial.
While there are treatments available for the clinical consequences of human papillomavirus HPV ie, genital warts, lesions, and cancers , there are no accepted treatments available against asymptomatic HPV, the most common sexually transmitted infection [ 1 ].
HPV infections are the causal precursors of clinical lesions and cancer of the cervix, anus, and oropharynx, which lead to significant morbidity and mortality worldwide [ 1 ]. Some groups, such as men living with human immunodeficiency virus HIV and gay, bisexual, or other men who have sex with men gbMSM , are at a high risk of acquiring HPV and developing HPV-related lesions and cancers [ 2β5 ].
The anti-HPV activity of carrageenan was demonstrated in in vitro and in vivo studies, as well as in clinical studies conducted in women [ 6 ]. This sulfated polysaccharide is structurally similar to heparan-sulfate proteoglycan, an HPV cell attachment factor.
