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Official websites use. Share sensitive information only on official, secure websites. Early evidence suggests the efficacy of voriconazole for chronic pulmonary aspergillosis CPA. We conducted a prospective, open, multicenter trial to evaluate the efficacy and safety of voriconazole for proven CPA in minimally or non-immunocompromised patients. Patients received voriconazole mg twice daily for a period of 6β12 months and were followed for 6 months after the end of therapy EOT.
Forty-one patients with confirmed CPA were enrolled. All patients had A. By EOT, five patients had died from comorbidities and seven had discontinued voriconazole due to toxicity. Clinical symptoms and quality of life also improved during treatment.
Voriconazole is effective for CPA, with acceptable toxicity. The response rate is higher and obtained more rapidly in necrotizing than cavitary forms. The online version of this article doi The clinical spectrum of Aspergillus disease ranges from mild allergic manifestations to rapidly evolving invasive infections.
While less studied, chronic pulmonary aspergillosis CPA seems to be more frequently encountered in patients with a history of lung disease. As chronic disabling disease, CPA primarily affects middle-aged patients who have a multitude of underlying pulmonary conditions and who are not or only minimally immunosuppressed [ 1 , 2 ].
Advances in medical imaging have allowed better distinction between the different types of CPA, and, despite some overlap, classification into distinct entities is possible [ 1 ]: simple aspergilloma fungus ball , chronic cavitary pulmonary aspergillosis CCPA; also known as complex aspergilloma , chronic necrotizing pulmonary aspergillosis CNPA; also known as semi-invasive or subacute invasive aspergillosis , chronic fibrosing pulmonary aspergillosis an end result of untreated CCPA and, occasionally, also CNPA , and tracheobronchial aspergillosis TBA [ 1 , 3 , 4 ].