Background: There are many effective topical and systemic therapies for acne rosacea. Topical zinc sulfate and tea lotion have been used in treatment of acne vulgaris. Patients and Methods: This single, blinded, comparative therapeutic clinical trial was carried out in the Department of Dermatology—Baghdad Teaching Hospital from June December Patient with severe acne rosacea were excluded from the study.
Results: Eighteen patients with acne rosacea completed the study with their ages ranging from 26 - 70 For Group A and Group B were Conclusion: Five percent zinc sulfate solution was a good alternative remedy to be used in patients with acnerosacea. Most recently a role of Helicobacter pylori H.
It is suggested that there is an etiological relationship between acne rosacea and H. There are many topical and systemic therapies of rosacea all might induce full recovery but unfortunately either relapse rate is high or there will be persistent erythema, these therapies include: avoidance of irritants, protection against sunlight [4], ,facial massage [4], diet, camouflage, topical antibiotics, topical metronidazole [4]topical retinoid [4], Azeliac acid, Tacrolimus [4], Permethrin, oral antibiotics [4], oral metronidazole [4], oral retinoids, antihypertensive drugs, spironolactone [6], dapsone, steroids [4] and surgical treatment [4].
Zinc is one of essential trace elements [7] that forms an integral part of several enzymes and cofactors which is an essential element in cell growth [8]. After application for 72 hours, percutaneous absorption of zinc sulfate results in increase in zinc concentration in whole skin and epidermis. The more zinc applied to the skin, the greater the increase in epidermal zinc level. Topical zinc ions traverse skin and can be found in dermis and blood. Zinc oxide is extremely insoluble and would not be expected to be similarly active [9].
Zinc sulfate has been introduced into dermatology as effective therapy for many specific dermatoses: Two percent zinc sulfate solution was found to be effective as an intralesional therapy for cutaneous leishmaniasis and verruca vulgaris with cure rate Oral zinc sulfate solution has been successfully tried in the treatment of cutaneous leishmaniasis, acne rosacea and viral warts [15,16].
