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Metrics details. Cognition is closely associated with physical function. These participants were from four MAPT groups multidomain interventions [physical activity and nutritional counselling, and cognitive training], omega-3 supplementation, multidomain plus omega-3 supplementation and control group and had received a 3-year intervention, followed by a 2-year observational follow-up.
Physical function was evaluated as gait speed 4-m usual-pace walk test and chair-stand time 5-time maximal chair-stand test. Multivariable regressions and mixed-effects linear models were used for the analysis.
Decreased physical function has been associated with cognitive impairment in older adults [ 1 , 2 ]. Yet, no association was found with chair-stand [ 7 ]. However, no study has been performed to examine this association in an older population. Meanwhile, a recent research by de Wolf et al. Written consent forms were obtained from all participants.
Outcome measures were evaluated at baseline, the 6th month and each year during the 3-year intervention period and the 2-year observational follow-up.
Data of outcome measures collected at the same time point and after blood tests were used in this study. For the rest of the participants, plasma markers were measured using samples from the second year. Blood samples were collected on the same day as cognitive and physical function evaluation. The cut-off value of NfL was determined as the upper quartile of our participants.