Official websites use. Share sensitive information only on official, secure websites. Correspondence: aaaljudaibi uj. Multidrug-resistant MDR bacteria are one of the most serious threats to public health, and one of the most important types of MDR bacteria are those that are acquired in a hospital, known as nosocomial. This study aimed to isolate and identify MDR bacteria from selected hospitals in Jeddah and analyze their antibiotic-resistant genes.
Bacteria were collected from different sources and wards of hospitals in Jeddah City. Phoenix BD was used to identify the strains and perform susceptibility testing.
Identification of selected isolates showing MDR to more than three classes on antibiotics was based on 16S rRNA gene and whole genome sequencing. Genes conferring resistance were characterized using de novo and pan-genome analyses. In total, we isolated bacterial strains, of which 75 Among the Gram-negative bacteria, K.
Of the Gram-positive bacteria, S. Taken together, our results illustrated that MDR Gram-negative bacteria are the most common cause of nosocomial infections, while MDR Gram-positive bacteria are characterized by a wider antibiotic resistance spectrum. Keywords: MDR, antibiotics, resistance, E. Antibiotic resistance develops from the abuse and overuse of antibiotics. Specifically, a selection of bacteria resistant to most forms of antibiotics emerges from the widespread and unjustified use of broad-spectrum antibiotics [ 1 ].
In a clinical environment, such as in hospitals, the overuse of antibiotics, even under controlled administration, breeds antibiotic resistance. More alarming is the presence of multidrug-resistant MDR bacteria, which refers to bacteria that exhibit resistance to at least three different classes of antimicrobials [ 2 ].
