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Official websites use. Share sensitive information only on official, secure websites. Correspondence: madleen. In contrast to obesity, which is very frequent, lipomatosis and lipodystrophy syndromes are rare diseases of adipose tissue.
Lipodystrophy syndromes are characterized by metabolic abnormalities associated with partial or generalized lipoatrophy. Lipomatosis is defined by the presence of several body lipomas without lipoatrophy. They have raised little clinical interest despite the non-negligible consequences of DD on quality of life.
The main clinical presentation of these diseases includes multiple lipomas, which are painful in DD in contrast to RLML. The two diseases are frequently associated with obesity and metabolic syndrome, with hypertension, diabetes, or dyslipidemia.
The long-term course of the diseases remains poorly described. Most cases are sporadic. No specific treatment has been identified, as the pathophysiology remains unknown. Nevertheless, low-grade fat inflammation and specific abnormalities such as hyperbasophilia deserve further investigation.
The aim of this review is to analyze the available literature on the topic. In recent decades there has been renewed interest in adipose tissue, and various diseases relating to its development have been reported. In contrast to common obesity, lipomatosis and lipodystrophy syndromes are rare [ 1 ]. Lipodystrophy syndromes are characterized by metabolic abnormalities such as insulin resistance, hypertriglyceridemia, and fatty liver due to the limited ability of the subcutaneous adipose tissue to store triglycerides.