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Back to Health A to Z. Erythema multiforme is a skin condition that can be caused by an infection or some medicines. It usually gets better on its own in 2 to 4 weeks. Sometimes you can get the rash inside your mouth or on your lips, eyes, anus or genitals. This can be painful. You can call or get help from online. These may be signs of a serious reaction and may need immediate treatment in hospital. Ask someone to drive you or call and ask for an ambulance.
Erythema multiforme is usually caused by an infection, such as the herpes simplex virus which also causes cold sores or a bacteria that causes lung conditions like pneumonia. It can sometimes be caused by some vaccines or medicines such as non-steroidal anti-inflammatory drugs NSAIDs , antibiotics, statins and medicines for epilepsy.
If it's caused by a medicine, you usually need to stop taking it. But do not stop taking any medicines without talking to a doctor first. Page last reviewed: 11 April Next review due: 11 April Erythema multiforme. Check if it's erythema multiforme The main symptom of erythema multiforme is a rash. The rash usually appears on your hands and feet, and spreads to your tummy, chest, back or face.
It might feel itchy or like it's burning. Non-urgent advice: See a GP if:. You think you have erythema multiforme and: the rash is inside your mouth or on your lips, eyes, anus or genitals the rash is painful you're finding it difficult to eat or pee you have a high temperature or body aches and pain the rash appeared after your started taking a new medicine You can call or get help from online. Bring any medicines you take with you.