Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Evidence indicates that the microbiome plays a significant role in HIV immunopathogenesis and associated complications. One hundred and thirty oral and anal DNA-derived samples were obtained from 78 participants and subjected to shotgun metagenomics sequencing for further microbiome analysis.
Results confirm the occurrence of oncogenic viromes in this high HIV-risk population. The oral microbiome in HIV-associated cases exhibited an enrichment of bacteria associated with periodontal disease pathogenesis. Conversely, anal bacteria showed a significant decrease in HIV-infected subjects Coprococcus comes, Finegoldia magna, Blautia obeum, Catenibacterium mitsuokai.
TGW showed enrichment in species related to sexual transmission, which concurs that most recruited TGW are or have been sex workers. Prevotella bivia and Fusobacterium gonidiaformans were positively associated with anal precancerous lesions among HIV-infected subjects. The enrichment of Holdemanella biformis and C.
Metabolic pathways were distinctly affected by predominant factors linked to sexual behavior or HIV pathogenesis. Conclusions: Identified microbial features at accessible sites are potential biomarkers for predicting precancerous anal lesions and therapeutic targets for HIV immunopathogenesis.
The human body harbors complex microbial communities that ensure vital functions for the host and may affect health and disease susceptibility by modulating physiological homeostasis, energy metabolism, and immune-related bioprocess 1 , 2.
