Metrics details. Chemotherapy-induced peripheral neurotoxicity CIPN is the most common adverse effect in patients undergoing chemotherapy, and no effective interventions are currently available for its prevention and treatment.
Non-pharmacological therapies appear to be beneficial for the prevention and treatment of CIPN, but it remains unclear which therapy is most effective. The aim of this study was to identify the most effective non-pharmacological therapy for CIPN patients. The primary outcomes included pain and peripheral neuropathological symptoms, and the secondary outcomes included quality of life, sensory and motor symptoms.
The pairwise analysis and a network meta-analysis were performed using a random effects model. A total of 46 articles were included in this study, involving 2, participants. Massage was also more effective than other non-pharmacological therapies in improving quality of life, sensory and motor symptoms.
According to our study, massage has advantages in alleviating pain, improving quality of life, and improving peripheral neuropathological symptoms and has better effect than other non-pharmacological interventions, representing certain clinical significance. However, the results of this study should be interpreted with caution due to the limitations of the included studies. In the future, more high-quality multi arm randomized controlled trials can be attempted to provide direct comparisons of the relative effects of non-pharmacological interventions.
Peer Review reports. Chemotherapy is one of the most commonly used anti-cancer treatments. Chemotherapy-induced peripheral neuropathy CIPN refers to a dose-limiting adverse effect that commonly occurs in patients receiving neurotoxic chemotherapies such as taxane, platinum agents, vinca alkaloids, thalidomide, and bortezomib. CIPN is clinically characterized by varying degrees of sensory, motor, and autonomic nervous dysfunction.
