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No use, distribution or reproduction is permitted which does not comply with these terms. As changes in cerebral function measured by resting-state magnet resonance imaging rs-fMRI are known in ALS, we investigated whether group differences in resting-state functional connectivity RSFC networks could be observed between ALS patients with different cognitive profiles against healthy controls HC.
Furthermore, we correlated cognition and motor functioning with network connectivity. Similar patterns of hypoconnectivity in the bilateral motor cortices and frontotemporal emerged when comparing the ALSci and ALS-FTD patients to those not cognitively impaired. Hyperconnectivity in the DMN temporal gyrus correlated with worse global cognition; moreover, hyperconnectivity in the VAN thalamus, insula, and putamen correlated with worse shifting ability.
Better-preserved motor function correlated with higher MN connectivity. Resting-state functional connectivity differs between cognitive profiles of ALS and is directly associated with clinical presentation, specifically with motor function, and cognitive shifting. Keywords: amyotrophic lateral sclerosis ALS , resting-state functional magnetic resonance imaging, cognition, cognitive dysfunction, frontotemporal lobar degeneration. Cognitive impairment in non-demented ALS patients characteristically includes executive and language deficits Beeldman et al.
The revised consensus criteria for the diagnosis of ALS propose a classification scheme based on deficits in specific cognitive domains Strong et al. Shen et al. Schulthess et al.
