To browse Academia. ALT levels were normal or only slightly elevated in the subjects described by Lazizi et al,4 to which Maeland and colleagues refer. American Journal of Obstetrics and Gynecology, In the past decades, several studies have identified asthma as a risk factor for several poor fetal and maternal outcomes. A consensus exists on favoring the use of asthma medications during pregnancy to maintain asthma under control to prevent adverse maternal and fetal outcomes.
An assessment of the published literature on maternal asthma medications and the risk of major congenital malformations revealed more data on the safety of short-acting beta2-agonists SABA and inhaled corticosteroids ICS during pregnancy compared to long-acting beta2-agonists LABA , as well as a paucity of data on the fetal safety of combination therapies e.
A three-part research program was developed to fill this knowledge gap and answer other intriguing questions we faced, adding necessary evidence in this field. In the first p Glutamine is a conditionally essential amino acid for very low-birth weight infants by virtue of its ability to play an important role in several key metabolic processes of immune cells and enterocytes.
Although glutamine is known to be used to a great extend, the exact splanchnic metabolism in enterally fed preterm infants is unknown. We hypothesized that preterm infants show a high splanchnic first-pass glutamine metabolism and the primary metabolic fate of glutamine is oxidation. Splanchnic and whole-body glutamine kinetics were assessed by plasma isotopic enrichment of [U C]glutamine and [ 15 N 2 ]glutamine and breath 13 CO 2 enrichments.
Dietary glutamine is used to a great extent by the splanchnic tissues in preterm infants and its carbon skeleton has an important role as fuel source. Aims Insulin glargine IG , with its non-peaking action profile, might be useful in diabetic pregnancy.
