Official websites use. Share sensitive information only on official, secure websites. As vertebrate genome sequences near completion and research refocuses to their analysis, the issue of effective genome annotation display becomes critical. This browser displays assembly contigs and gaps, mRNA and expressed sequence tag alignments, multiple gene predictions, cross-species homologies, single nucleotide polymorphisms, sequence-tagged sites, radiation hybrid data, transposon repeats, and more as a stack of coregistered tracks.
Text and sequence-based searches provide quick and precise access to any region of specific interest. Secondary links from individual features lead to sequence details and supplementary off-site databases. One-half of the annotation tracks are computed at the University of California, Santa Cruz from publicly available sequence data; collaborators worldwide provide the rest.
Users can stably add their own custom tracks to the browser for educational or research purposes. The conceptual and technical framework of the browser, its underlying MYSQL database, and overall use are described. The web site currently serves over 50, pages per day to over different users. We are fortunate to live in a time when the vast majority of the human genome has been sequenced, is freely available, and where work proceeds rapidly to fill in the remaining gaps.
The public mapping and sequencing efforts have spanned a decade and involved thousands of people Consortium ; McPherson et al. The end result of the sequencing efforts will be three billion A's, Cs, Gs, and Ts in a particular order that somehow contains instructions for building a human body.
Over 2. Finding which of the 2. For the most part, researchers would prefer to view the genome at a higher levelβat the level of an exon, a gene, a chromosome band, or a biochemical pathway. The base-by-base view is best reserved for preparing primers for experiments or looking for DNA motifs associated with particular functions.
